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. 2020 May 25;18:78. doi: 10.1186/s12964-020-00547-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — STAT4 activation depends differently on the density of IL12 receptor complexes in 2D6 cells than in B16F0 cells while Akt activation in 2D6 and B16F0 cells exhibit similar dependence on the density of IL12 receptor complexes. Phosphorylation of STAT4 (panel a) and Akt (panel b) in 2D6 (o) and B16F0 (x) cells stratified by the density of IL12 receptor complexes: IL12RB1:IL12RB2 in 2D6 cells and IL12RB2:IL12RB2 in B16F0 cells. Colors indicate untreated cells (black) and stimulation with 7 (blue), 100 (red), and 300 (green) ng/mL of IL-12. The experimental results with the highest phosphorylation levels were regressed to Eq. 12 (black lines), with the resulting equation corresponding to the maximum likelihood fit indicated