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. 2020 May 25;18:78. doi: 10.1186/s12964-020-00547-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — The ratio of IL12RB2 to IL12RB1 mRNA is increased in human malignant melanocytes compared to CD4+ and CD8+ T cells isolated from melanoma tumors. Single cells were isolated from 31 melanoma tumors and subject to single-cell RNA-seq analysis. a Scatter plot for IL12RB1 and IL12RB2 mRNA expression in TPM among malignant melanocytes (n = 2018, black), NK cells (n = 92, red), CD4+ T cells (n = 856, blue), and CD8+ T cells (n = 1759, yellow). b Using the subset with non-zero values for the expression of both genes, the distribution in the ratio of IL12RB2:IL12RB1 expression among malignant melanocytes (n = 418, black), NK cells (n = 22, red), CD4+ T cells (n = 187, blue), and CD8+ T cells (n = 181, yellow) is shown