Table 1.

Circadian clock components and their cognate ligand or small molecule modulators

DRUG NAME	CIRCADIAN CLOCK TARGET GENE	ACTIVITY	References	Effect on circadian clock assessed? Y/N
Nobiletin	RORs	AGONIST	[105, 106]	Y
SR1001	RORs	INVERSE AGONIST	[107]	Y
SR1078	ROR-α/γ	AGONIST	[108]	N
SR3335	ROR-α	INVERSE AGONIST	[109]	N
SR2211	ROR-γ	INVERSE AGONIST	[110]	N
XY018	ROR-γ	INVERSE AGONIST	[111]	N
XY011/8k	ROR-γ	ANTAGONIST	[112]	N
GSK805	ROR-γ	ANTAGONIST	[113]	N
SR 1555	ROR-γ	INVERSE AGONIST	[114]	N
LYC-53772	ROR-γ	AGONIST	[115]	N
LYC-54143	ROR-γ	AGONIST	[115]	N
Ursolic acid	ROR-γ	INVERSE AGONIST	[116]	N
Digoxin	ROR-γ	INVERSE AGONIST	[117]	N
Compound 1a	ROR-γ	AGONIST	[118]	N
Compound 1b	ROR-γ	AGONIST	[118]	N
Compound 1c	ROR-γ	AGONIST	[118]	N
Inhibitor Y	ROR-γ	INVERSE AGONIST	[118]	N
JNJ-54271074	ROR-γ	INVERSE AGONIST	[119]	N
Compound 1	ROR-β and ROR-γ	INVERSE AGONIST	[120]	N
GSK2945	REV-ERBα	AGONIST	[121]	Y
GSK0999	REV-ERBα	AGONIST	[121]	Y
GSK5072	REV-ERBα	AGONIST	[121]	Y
REV-ERBα	REV-ERBs	ANTAGONIST	[122]	Y
GSK2667	REV-ERBα	AGONIST	[121]	N
SR9011	REV-ERBs	AGONIST	[123]	Y
SR9009	REV-ERBs	AGONIST	[123]	Y
GSK4112	REV-ERBα	AGONIST	[124]	Y