Table 5.

Main results.

Study	Diagnosis	Therapy	MAIN RESULTS
(20)	Major Depressive Disorder	(IPT)	17 patients had a reduction of the least 50% on the baseline Hamilton scale score and were defined as “responders” after psychotherapy. BDNF had no meaningful difference between the responders and non-responders groups. Age, sex, HAMD, subject as inpatient or outpatient, number of previous depressive events, or pharmacological treatment before the therapy had no meaningful correlation with BDNF levels. There were no association between BDNF levels and depression severity
(25)	Major Depressive Disorder	(CBT)	There was a significantly depression symptoms reduction after psychotherapy. There were no significant differences between pre and post psychotherapy intervention BDNF levels.
(26)	Post-traumatic stress disorder	(ET)	Psychotherapy, as only treatment, in patients with PTSD did not change BDNF levels in 12 weeks. Exposure therapy associated with physical activity increased the BDNF levels in patients.
(22)	Post-traumatic stress disorder	(EMDR)	There were no meaningful changes on BDNF plasma levels after psychotherapy, but responders presented higher BNDF plasma levels than non-responders. Anxiety, phobia, and dissociation levels were significantly reduced after EMDR. BDNF basal levels presented correlation with the depression and anxiety estimated response
(21)	Bulimia Nervosa	(CBT)	BDNF levels in patients with bulimia increased after treatment. There were no differences between BDNF levels in inpatients and outpatients There was a reduction in the frequency of self-induced vomiting, laxatives using, and compulsive eating episodes after therapy. There were no significant changes on the Beck Depression Inventory and Eating Disorder Inventory scores, except for “Drive for Thinness”.
(23)	Borderline Disorder	(I-DBT)	Plasma BDNF levels in subjects with BPD were higher than in the control group There was an inversely proportional decrease of BDNF levels in response to psychotherapy Non-responders had a reduction of BDNF levels after psychotherapy and, responders, had an increase, both, not significant.
(27)	Major Depressive Disorder	(CBT)	After the treatment, the group that underwent pharmacotherapy combined with psychotherapy presented a most expressive depressive symptom reduction in comparison to the submitted only to the pharmacological treatment. Before the treatment, both control and intervention group had BDNF levels with no significant differences. After intervention, the group with psychotherapy associated presented a significantly higher increase of BDNF
(24)	Sleep Disorder	(CBT)	The group that had an improvement on sleep patterns had a not significant BDNF increase, while in the group that its sleep patterns got worse, BDNF levels did not change.

CBT, Cognitive-Behavioral Therapy; EMDR, Eye Movement Desensitization and Reprocessing; ET, Exposure Therapy; I-DBT, Intensive dialectical behavior therapy; IPT, Interpersonal therapy.