TABLE 3.
Taxa | Parenteral toltrazuril | Oral toltrazuril | Control | SEM | Treatment, P-value |
Phylum | |||||
p__Firmicutes | 59.17a | 59.06a | 34.29b | 4.714 | <0.001 |
p__Bacteroidetes | 27.73 | 25.08 | 26.64 | 3.730 | 0.886 |
p__Fusobacteria | 7.96b | 5.54b | 27.83a | 3.544 | <0.001 |
p__Proteobacteria | 2.62b | 6.88a | 9.84a | 1.386 | 0.003 |
p__Actinobacteria | 1.14 | 1.88 | 0.77 | 0.353 | 0.105 |
p__Verrucomicrobia | 0.55 | 0.17 | 0.30 | 0.347 | 0.738 |
p__Synergistetes | 0.089b | 0.61a | 0.039b | 0.154 | 0.029 |
p__Spirochaetes | 0.268 | 0.213 | 0.176 | 0.110 | 0.830 |
p__Planctomycetes | 0.175 | 0.226 | 0.054 | 0.077 | 0.291 |
p__Lentisphaerae | 0.138b | 0.226a | 0.049b | 0.040 | 0.016 |
p__Euryarchaeota | 0.100a | 0.113a | 0.007b | 0.031 | 0.044 |
Family | |||||
f_Fusobacteriaceae | 7.73b | 5.87b | 26.86a | 3.009 | <0.001 |
f_Ruminococcaceae | 16.79a | 15.65a | 4.15b | 2.069 | <0.001 |
f_Lachnospiraceae | 11.30a | 10.47a | 4.19b | 1.174 | <0.001 |
f_Veillonellaceae | 2.84b | 3.18b | 10.18a | 1.792 | 0.010 |
f_S24-7 | 6.48a | 4.08a | 0.80b | 0.894 | <0.001 |
f_Clostridiaceae | 3.97a | 3.24a | 0.94b | 0.964 | 0.079 |
f_Erysipelotrichaceae | 3.34a | 3.58a | 0.56b | 0.584 | 0.002 |
f_Enterobacteriaceae | 1.18b | 4.72a | 1.74b | 0.928 | 0.029 |
f_Campylobacteraceae | 0.44ab | 0.003b | 3.57a | 1.118 | 0.065 |
f_Bifidobacteriaceae | 0.099b | 0.57a | 0.10b | 0.106 | 0.006 |
f_Synergistaceae | 0.090b | 0.64a | 0b | 0.144 | 0.010 |
f_Victivallaceae | 0.13ab | 0.22a | 0.026b | 0.036 | 0.003 |
f_Methanobacteriaceae | 0.098a | 0.11a | 0.012b | 0.029 | 0.038 |
f_Micrococcaceae | 0.11a | 0.058ab | 0.010b | 0.020 | 0.006 |
Genus | |||||
g_Fusobacterium | 7.75b | 5.90b | 26.88a | 3.012 | <0.001 |
g_Oscillospira | 7.86a | 6.91a | 1.55b | 1.099 | <0.001 |
f_Lachnospiraceae; g_ | 5.76a | 5.44a | 1.27b | 0.819 | <0.001 |
g__S24-7 | 6.52a | 4.10a | 0.81b | 0.899 | <0.001 |
g_Ruminococcus | 4.23a | 4.32a | 1.22b | 0.905 | 0.034 |
f_Ruminococcaceae; g_ | 3.92a | 3.62a | 0.97b | 0.845 | 0.036 |
g_Escherichia | 1.16b | 4.69a | 1.73b | 0.923 | 0.029 |
g_[Eubacterium] | 2.24a | 2.35a | 0.27b | 0.458 | 0.005 |
g_[Ruminococcus] | 1.85a | 1.89a | 0.53b | 0.326 | 0.008 |
g_Anaerovibrio | 0.080b | 0.056b | 3.93a | 1.077 | 0.023 |
g_Rikenella | 1.30a | 1.95a | 0.51b | 0.322 | 0.015 |
g_SMB53 | 1.69a | 1.40a | 0.23b | 0.368 | 0.020 |
f_Christensenellaceae; g_ | 1.56a | 1.30a | 0.19b | 0.403 | 0.050 |
g_Blautia | 1.50a | 0.59b | 0.46b | 0.291 | 0.030 |
g__Butyricimonas | 1.12a | 1.11a | 0.36b | 0.220 | 0.030 |
g__Desulfovibrio | 0.69a | 0.76a | 0.17b | 0.106 | <0.001 |
o_Bacteroidales; f_; g_ | 0.84a | 0.50ab | 0.055b | 0.213 | 0.042 |
f_Mogibacteriaceae; g_ | 0.46b | 0.75a | 0.088a | 0.147 | 0.014 |
g_Synergistes | 0.091b | 0.64a | 0b | 0.145 | 0.010 |
g_Bifidobacterium | 0.010b | 0.44a | 0.091b | 0.079 | 0.007 |
g_Dialister | 0.005b | 0.056b | 0.49a | 0.067 | <0.001 |
g_Methanobrevibacter | 0.099a | 0.11a | 0.012b | 0.029 | 0.039 |
g_Rothia | 0.11a | 0.059ab | 0.011b | 0.020 | 0.006 |
Different superscript letters mark significant differences at P < 0.05. SEM: standard error of the mean. Bold numbers indicate statistically significant values (P ≤ 0.05).