Table 2.
Frequencies of Predicted Phenotypes of all Phased CYP2A6 Diplotypes Found in SCF Subgroups (n = 269)
| Southwestern | Northern | Western | Southeastern | Interior | Lower 48 | SCF | Phenotype class | |
|---|---|---|---|---|---|---|---|---|
| n = 40 | n = 52 | n = 58 | n = 33 | n = 56 | n = 30 | n = 269 | ||
| *1/*1 | 10.0 | 3.8 | 13.8 | 0.0 | 12.5 | 3.3 | 8.2 | Normal |
| *1/*14 | 12.5 | 0.0 | 0.0 | 3.0 | 0.0 | 0.0 | 2.2 | Normal |
| *1/*1B | 32.5 | 32.7 | 24.1 | 39.4 | 28.6 | 40.0 | 31.6 | Normal |
| *1B/*1B | 20.0 | 25.0 | 24.1 | 45.5 | 19.6 | 13.3 | 24.2 | Normal |
| *1B/*1B+*14 | 0.0 | 1.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | Normal |
| *1/*21 | 0.0 | 1.9 | 0.0 | 0.0 | 1.8 | 6.7 | 1.5 | Normal |
| *1/*9 | 10.0 | 9.6 | 6.9 | 6.1 | 26.8 | 30.0 | 14.5 | Intermediate |
| *1/*12 | 0.0 | 1.9 | 5.2 | 3.0 | 0.0 | 0.0 | 1.9 | Intermediate |
| *1/*28 | 0.0 | 1.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | Intermediate |
| *1/*35 | 2.5 | 1.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.7 | Intermediate |
| *1B/*1B+*10 | 0.0 | 3.8 | 0.0 | 0.0 | 3.6 | 0.0 | 1.5 | Intermediate |
| *1B/*1B+*35 | 0.0 | 1.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | Intermediate |
| *14/*18 | 2.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | Intermediate |
| *1/*2 | 0.0 | 1.9 | 0.0 | 0.0 | 3.6 | 0.0 | 1.1 | Slow |
| *1/*4 | 2.5 | 3.8 | 6.9 | 0.0 | 0.0 | 0.0 | 2.6 | Slow |
| *1B/*4 | 0.0 | 3.8 | 5.2 | 0.0 | 0.0 | 0.0 | 1.9 | Slow |
| *1B+*2/*1B+*9 | 0.0 | 0.0 | 1.7 | 0.0 | 0.0 | 0.0 | 0.4 | Slow |
| *2/*9 | 2.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | Slow |
| *4/*9 | 0.0 | 0.0 | 3.4 | 0.0 | 0.0 | 0.0 | 0.7 | Slow |
| *4/*14 | 0.0 | 0.0 | 0.0 | 0.0 | 1.8 | 0.0 | 0.4 | Slow |
| *10/*9+*18 | 2.5 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | Slow |
| *4/*1B+*5 | 2.5 | 0.0 | 1.7 | 0.0 | 0.0 | 0.0 | 0.7 | Poor |
| *4/*4 | 0.0 | 0.0 | 3.4 | 0.0 | 0.0 | 0.0 | 0.7 | Poor |
| *4/*5 | 0.0 | 0.0 | 3.4 | 0.0 | 0.0 | 0.0 | 0.7 | Poor |
| *4/*5+*9 | 0.0 | 1.9 | 0.0 | 0.0 | 0.0 | 0.0 | 0.4 | Poor |
| *1x2A | 0.0 | 1.9 | 0.0 | 3.0 | 0.0 | 0.0 | 0.7 | Rapid |
| *9/*1x2A | 0.0 | 0.0 | 0.0 | 0.0 | 1.8 | 0.0 | 0.4 | Normal |
| *1/*1+*S1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.3 | 0.4 | Unknown |
| *9/*1+*S1 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 3.3 | 0.4 | Unknown |
We obtained activity data for CYP2A6 from the old CYP nomenclature website (now PharmVar; https://www.pharmvar.org), where none = 0, decreased = 0.5, and normal = 1. To convert from activity score to phenotype class (or metabolizer phenotype), we used this criteria: Poor (activity score = 0), Slow (activity score 0 to <1), Intermediate (activity score 1 to <2), Normal (activity score 2 to <3), and Rapid (activity score > 3).