Table 2.

Replication of candidates for FTND and TTFC

	Marker Info						Discovery			Replication			Combined
	CHR	BP	SNP	EA	NEA	GENE	β	SE	p	β	SE	p	β	SE	p
FTND	2	26,860,822	rs17005545	T	C	CIB4	−0.23	0.05	6.99E-07	−0.16	0.10	0.1078	−0.22	0.04	2.68E-07
	11	97,713,579	rs117029742	T	C	BG182718	−0.64	0.12	1.04E-07	0.29	0.19	0.1370	−0.38	0.10	1.73E-04
	15	78,882,925	rs16969968	G	A	CHRNA5	−0.21	0.02	3.96E-19	−0.29	0.04	1.19E-11	−0.23	0.02	4.24E-28
	18	28,355,510	rs28510557	C	T	DSC3	−0.10	0.02	1.23E-06	0.02	0.04	0.6672	−0.08	0.02	3.19E-05
TFC	1	40,464,894	rs34022242	C	G	MFSD2A	−0.13	0.02	2.48E-07	−0.05	0.04	0.1643	−0.11	0.02	3.53E-07
	1	68,862,622	rs3125927	G	A	RPE65	−0.05	0.01	5.24E-07	0.02	0.02	0.2298	−0.03	0.01	2.25E-04
	4	103,715,385	rs223441	C	T	CISD2	0.05	0.01	4.66E-06	−0.01	0.02	0.4071	0.03	0.01	4.42E-04
	4	186,514,078	rs28567706	C	G	SORBS2	0.49	0.09	4.05E-08	0.08	0.07	0.2745	0.23	0.05	2.22E-05
	8	42,527,386	rs11785369	A	C	CHRNB3	0.09	0.02	8.83E-08	0.06	0.03	2.46E-02	0.08	0.01	7.88E-09
	9	21,673,859	rs184042824	C	T	MIR31HG	−0.31	0.06	5.70E-08	−0.03	0.09	0.7136	−0.23	0.05	1.53E-06
	11	97,713,579	rs117029742	T	C	BG182718	−0.30	0.05	1.02E-08	0.07	0.07	0.3574	−0.17	0.04	5.28E-05
	14	44,608,436	rs10133756	C	G	AA333164	−0.31	0.05	4.11E-09	0.04	0.07	0.5277	−0.18	0.04	1.26E-05
	15	78,882,925	rs16969968	G	A	CHRNA5	−0.06	0.01	6.21E-09	−0.10	0.02	2.84E-10	−0.07	0.01	1.05E-17
	17	51,940,280	rs2877510	C	T	KIF2B	0.06	0.01	6.36E-06	0.01	0.02	0.5735	0.04	0.01	4.45E-05
	20	15,901,883	rs6135601	G	T	MACROD2	−0.13	0.03	5.53E-06	0.02	0.04	0.5457	−0.08	0.02	8.18E-04
	22	42,058,846	rs132786	G	A	XRCC6	−0.07	0.01	4.07E-06	0.02	0.02	0.2141	−0.03	0.01	5.29E-03

EA, effect allele; NEA, noneffect allele; EAF, effect allele frequency; BP, base-pair position according to GRCh37/hg19; FTND, Fagerström Test for Nicotine Dependence; TTFC, time to first cigarette. Loci reaching GWAS significance (5E-8) were highlighted in bold.