Table 3.
Genes/loci showing convergent association between FTND and TTFC
| Marker Info | FTND | TTFC | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CHR | BP | SNP | EA | NEA | EAF | β | SE | p | β | SE | p |
GENE |
| 2 | 4,073,151 | rs13425218 | G | C | 0.68 | −0.13 | 0.03 | 3.80E-05 | −0.06 | 0.01 | 2.11E-05 | DA409732 |
| 2 | 137,983,050 | rs17269864 | C | A | 0.67 | −0.10 | 0.02 | 2.77E-06 | −0.04 | 0.01 | 3.17E-05 | THSD7B* |
| 2 | 185,787,483 | rs56321552 | G | C | 0.95 | 0.24 | 0.06 | 2.20E-05 | NL | NL | NL | ZNF804A** |
| 2 | 185,639,136 | rs78011041 | T | G | 0.97 | NL | NL | NL | 0.12 | 0.03 | 3.42E-05 | ZNF804A** |
| 2 | 221,852,642 | rs6709809 | G | A | 0.96 | −0.24 | 0.06 | 4.18E-05 | −0.13 | 0.03 | 2.59E-06 | — |
| 5 | 30,863,015 | rs4502841 | G | A | 0.48 | −0.09 | 0.02 | 1.46E-05 | −0.05 | 0.01 | 2.14E-06 | — |
| 5 | 92,486,203 | rs4526087 | C | G | 0.90 | 0.15 | 0.03 | 1.15E-05 | NL | NL | NL | — |
| 5 | 92,554,821 | rs193049029 | T | C | 0.98 | NL | NL | NL | −0.24 | 0.06 | 2.78E-05 | — |
| 8 | 42,527,386 | rs11785369 | A | C | 0.90 | 0.14 | 0.03 | 2.28E-05 | 0.09 | 0.02 | 8.83E-08 | CHRNB3-CHRNA6 |
| 9 | 136,789,062 | rs7847503 | A | G | 0.97 | −0.23 | 0.06 | 4.32E-05 | NL | NL | NL | VAV2 |
| 9 | 136,768,563 | rs10993850 | C | A | 0.91 | NL | NL | NL | 0.08 | 0.02 | 3.93E-05 | VAV2 |
| 11 | 72,301,503 | rs341047 | G | A | 0.88 | −0.14 | 0.03 | 3.07E-05 | −0.06 | 0.02 | 3.83E-05 | PDE2A |
| 11 | 97,713,579 | rs117029742 | T | C | 0.98 | −0.64 | 0.12 | 1.04E-07 | −0.30 | 0.05 | 1.02E-08 | BG182718 |
| 15 | 78,882,925 | rs16969968 | G | A | 0.64 | −0.21 | 0.02 | 3.96E-19 | −0.06 | 0.01 | 6.21E-09 | CHRNA5-CHRNA3-CHRNB4 |
| 16 | 6,124,714 | rs9927211 | G | C | 0.23 | −0.13 | 0.03 | 1.83E-05 | NL | NL | NL | RBFOX1 *** |
| 16 | 6,071,910 | rs12444143 | T | C | 0.40 | NL | NL | NL | −0.05 | 0.01 | 3.56E-05 | RBFOX1 *** |
| 17 | 51,926,097 | rs3966061 | C | T | 0.17 | 0.12 | 0.03 | 2.14E-05 | 0.06 | 0.01 | 1.46E-05 | KIF2B |
| 20 | 61,989,658 | rs45623037 | G | C | 0.92 | −0.21 | 0.05 | 2.75E-05 | NL | NL | NL | CHRNA4 |
| 20 | 60,522,424 | rs4925328 | T | G | 0.43 | NL | NL | NL | 0.05 | 0.01 | 4.78E-05 | CHRNA4 |
| 22 | 36,503,250 | rs16996373 | G | T | 0.84 | −0.12 | 0.03 | 3.18E-05 | −0.06 | 0.01 | 8.93E-06 | APOL3 |
EA, effect allele; NEA, noneffect allele; EAF, effect allele frequency; BP, base-pair position according to GRCh37/hg19; FTND, Fagerström Test for Nicotine Dependence; TTFC, time to first cigarette; NL, not listed because the p-value > 5 × 10−5; *, linked to alcohol addiction; 43 **, linked to schizophrenia; 58,59 ***, linked to cocaine addiction.42 Genes relevant to addictions or neuropsychiatric co-morbidities are highlighted in bold.