Table 4.
Summary of gene-association results
| Gene Information | FTND | TTFC | Functions* | ||||
|---|---|---|---|---|---|---|---|
| Name | Chr | Position | P_value | FDR q_value | P_value | FDR q_value | |
| RPE65 | 1 | 68894506 | 0.49513 | 1.0000 | 0.00004 | 0.0673 | congenital amaurosis |
| CHD1L | 1 | 146714290 | 0.04676 | 0.7808 | 0.00003 | 0.0636 | cancer gene |
| TTFCP2L1 | 2 | 121974163 | 0.89730 | 1.0000 | 0.00001 | 0.0279 | pluripotency, development |
| COPB2 | 3 | 139076432 | 0.00001 | 0.0229 | 0.64899 | 1.0000 | lung cancer |
| LOC102723704 | 4 | 103698193 | 0.08404 | 0.8275 | 0.00004 | 0.0673 | ncRNA |
| UBE2D3 | 4 | 103715539 | 0.12397 | 0.8807 | 0.00005 | 0.0674 | ubiquitination |
| LOC105377348 | 4 | 103750470 | 0.32928 | 1.0000 | 0.00006 | 0.0676 | ncRNA |
| CISD2 | 4 | 103790134 | 0.36281 | 1.0000 | 0.00004 | 0.0673 | intracellular calcium homeostasis |
| SLC9B1 | 4 | 103822084 | 0.51668 | 1.0000 | 0.00004 | 0.0673 | sodium/hydrogen exchanger |
| DNAH8 | 6 | 38683116 | 0.16941 | 0.9251 | 0.00006 | 0.0676 | sperm and respiratory cilia motility |
| AGR3 | 7 | 16899029 | 0.37663 | 1.0000 | 0.00008 | 0.0827 | cancer gene |
| RELN | 7 | 103112230 | 0.31646 | 1.0000 | 4.47E-06 | 0.0223 | schizophrenia, autism, cell adhesion |
| CHRNB3 | 8 | 42552561 | 0.03471 | 0.7313 | 0.00005 | 0.0674 | nicotinic receptor |
| MIR31HG | 9 | 21454266 | 0.03006 | 0.7241 | 0.00005 | 0.0676 | lncRNA, cancer regulation |
| LOC389765 | 9 | 88420916 | 0.06893 | 0.8117 | 0.00006 | 0.0698 | — |
| TMEM132B | 12 | 126106997 | 0.19739 | 0.9368 | 0.00009 | 0.0847 | intracranial aneurysm |
| SLC46A3 | 13 | 29274217 | 0.54791 | 1.0000 | 0.00004 | 0.0673 | Lysosome/cytoplasm transport |
| KLHL1 | 13 | 70274724 | 0.00271 | 0.4838 | 0.00002 | 0.0579 | calcium signaling, cancer |
| IREB2 | 15 | 78730517 | 9.55E-11 | 4.76E-07 | 0.00014 | 0.1254 | lung diseases |
| HYKK | 15 | 78799905 | 3.59E-17 | 8.93E-13 | 1.20E-07 | 9.92E-04 | lung diseases |
| PSMA4 | 15 | 78832746 | 7.80E-11 | 4.76E-07 | 1.76E-05 | 5.48E-02 | lung diseases |
| CHRNA5 | 15 | 78857861 | 1.53E-15 | 1.27E-11 | 9.51E-08 | 9.92E-04 | nicotinic receptor |
| CHRNA3 | 15 | 78887646 | 1.00E-15 | 1.25E-11 | 6.26E-08 | 9.92E-04 | nicotinic receptor |
| CHRNB4 | 15 | 78916635 | 1.47E-10 | 6.12E-07 | 2.60E-06 | 1.62E-02 | nicotinic receptor |
| INO80C | 18 | 33048290 | 0.07345 | 0.8117 | 1.01E-05 | 0.0359 | chromatin remodeling/silencing |
| SSTR4 | 20 | 23016056 | 0.23580 | 0.9667 | 2.32E-05 | 0.0579 | somatostatin receptors |
| CHRNA4 | 20 | 61974661 | 1.39E-06 | 0.0049 | 0.0013 | 0.3773 | nicotinic receptor |
| XRCC6 | 22 | 42017345 | 0.09636 | 0.8438 | 0.0001 | 0.0724 | cancer gene |
| NHP2L1 | 22 | 42069936 | 0.30160 | 0.9951 | 0.0001 | 0.0835 | chromatin remodeling/silencing |
| MEI1 | 22 | 42095517 | 0.42723 | 1.0000 | 0.0001 | 0.0676 | meiotic chromosome synapsis |
FTND, Fagerström Test for Nicotine Dependence; TTFC, time to first cigarette; *, functions relevant to smoking or neuropsychiatric co-morbidities are highlighted in bold. FDR q-values below 0.05 are highlighted in bold.