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. 2020 May 19;8:278. doi: 10.3389/fcell.2020.00278

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Copyright © 2020 Wang, Zhang, Xu, Yang, Xu, Liu, Li, Xie and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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hsa-miR-6768-5p overexpression eliminated the effect of hsa_circ_0000848 overexpression in HTR-8 cells. To confirm whether hsa_circ_0000848 acts by sponging hsa-miR-6768-5p, hsa_circ_0000848 overexpressing plasmid and hsa-miR-6768-5p mimics were co-transfected into HTR-8 cells to carry out rescue assays. Cells transfected with NC plus miR-NC or ov-circ_0000848 + miR-NC were used as controls. The results showed that hsa-miR-6768-5p overexpression eliminated the effect of hsa_circ_0000848 overexpression on migration, invasion (A), apoptosis (B) and protein abundance of MMP-2, MMP-9, cleaved caspase-3, cleaved caspase-9, BCL2 and BAX (C) in HTR-8 cells. *P < 0.05 using unpaired t-tests.