Extended Data Figure 4. Regional BBB Ktrans constant in all studied brain regions in APOE4 carriers and non-carriers (APOE3) in relation to vascular risk factors.
DCE-MRI BBB permeability, Ktrans constant, in the hippocampus (HC, a), parahippocampal gyrus (PHG, b), inferior temporal gyrus (ITG, c), superior frontal gyrus (SFG, d), caudate nucleus (CN, e), thalamus (Thal, f), striatum (Str, g), subcortical watershed normal-appearing white matter (Subcort. WS NAWM, h), corpus callosum (CC, i), and internal capsule (IC, j) in APOE3 (black, n=80) and APOE4 (red, n=42) carriers with 0-1 vascular risk factors (VRFs), and APOE3 (black, n=58) and APOE4 (red, n=51) carriers with 2+ VRFs. Violin plot continuous lines indicate median values and dotted lines indicate interquartile range. Significance by ANCOVAs for main effects and post-hoc comparisons controlling for age, sex, and education (ns=non-significant).