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Different types of shared loci for CHD and T2D. A. IRS1 locus where the same variants are associated with CHD and T2D. B. More complex structure of chromosome 9p21 locus, which houses overlapping signals for CHD and T2D as well as an independent signal for T2D (see also Figure 1). C. Loci involved in triglyceride metabolism. D. Multi-locus colocalization approach97 that revealed seven signals with consistent direction of effect and one locus with opposite effects on CHD and T2D.
