Table 1.
SNPs that are associated with both T2D and CHD with genome-wide significance on bivariate scan
| SNP | Nearest genes | Effect allele/other allele | CHD: OR | CHD: P value | T2D: OR | T2D: P value | Bivariate P value | Colocalization probability |
|---|---|---|---|---|---|---|---|---|
| rs7903146 | TCF7L2 | T/C | 1.04 (1.02-1.05) | 2.87E-05 | 1.35 (1.33-1.38) | 1.33E-219 | 2.64E-212 | 0.95 |
| rs1169288 (I27L) | HNF1A | C/A | 1.04 (1.03-1.06) | 3.86E-07 | 1.06 (1.04-1.08) | 9.25E-10 | 1.98E-12 | 0.69 |
| rs7202877 | CTRB1, CTRB2 | C/T | 1.06 (1.04-1.09) | 2.90E-06 | 1.06 (1.03-1.08) | 3.92E-09 | 6.33E-11 | 0.97 |
| rs2306374 | MRAS | C/T | 1.06 (1.04-1.08) | 2.35E-08 | 1.05 (1.02-1.07) | 6.51E-04 | 9.76E-09 | 0.55 |
| rs11556924 (R342H) | ZC3HC1 | C/T | 1.08 (1.06-1.10) | 3.28E-20 | 1.03 (1.01-1.05) | 4.94E-04 | 1.38E-19 | 0.63 |
| rs7985179 | GPC5, MIR17HG | T/A | 1.05 (1.02-1.08) | 6.37E-04 | 1.07 (1.05-1.10) | 3.72E-09 | 1.54E-09 | 0.54 |
| rs825476 | CCDC92 | T/C | 1.03 (1.02-1.05) | 2.96E-07 | 1.04 (1.03-1.06) | 2.21E-06 | 2.71E-09 | 0.98 |
| rs4420638 | APOE, APOC1 | G/A | 0.89 (0.85-0.93) | 1.76E-06 | 1.08 (1.05-1.11) | 8.82E-08 | 2.59E-13 | 0.99 |
Data are from Zhao et al.97 All loci have r2>0.7 between T2D and CHD associations and colocalization probability >0.5. Individual associations have P<1x10−3.