Table 3.
Laboratory characteristics of the non-surviving COVID-19 patients.
| Laboratory characteristics | Non-survivors (n = 44) | Flu (n = 22) | Non-flu (n = 22) | P-value |
|---|---|---|---|---|
| White blood cell count (×109/L) | 9.5 (6.1, 13.6) | 12.9 (8.9, 15.4) | 7.4 (5.1, 11.0) | 0.01 |
| Neutrophil count (×109/L) | 8.7 (5.1, 12.6) | 11.5 (7.5, 13.6) | 6.5 (4.0, 10.0) | 0.01 |
| Neutrophil >6.3 × 109/L | 30/44 (68.2) | 18/22 (81.8) | 12/22 (54.5) | 0.05 |
| Lymphocyte count (×109/L) | 0.5 (0.4, 0.8) | 0.6 (0.4, 0.8) | 0.5 (0.4, 0.7) | 0.64 |
| Lymphopenia <1 × 109/L | 41/44 (93.2) | 20/22 (90.9) | 21/22 (95.5) | 0.55 |
| C-reactive protein (mg/L) | 78.2 (47.4, 153.1) | 86.4 (48.4, 146.5) | 78.2 (48.9, 158.4) | 0.95 |
| C-reactive protein >10 mg/L | 41/44 (93.2) | 20/22 (90.9) | 21/22 (95.5) | 0.55 |
| ALT (U/L) | 28.5 (18.8, 40.5) | 27.5 (19.5, 33.8) | 35.0 (19.0, 42.3) | 0.31 |
| AST (U/L) | 45.0 (29.0, 59.5) | 40.0 (24.3, 52.0) | 48.0 (36.8, 63.5) | 0.12 |
| ALT>45 U/L or AST>35 U/L | 28/44 (63.6) | 13/22 (59.1) | 15/22 (68.2) | 0.53 |
| Creatinine (μmol/L) | 91.0 (72.8, 118.5) | 87.5 (67.3, 135.8) | 92.5 (79.5, 102.8) | 0.61 |
| Creatinine >1 × 106 μmol/L | 13/44 (29.5) | 10/22 (45.5) | 3/21 (14.3) | 0.03 |
| Cardiac troponin I (pg/mL) | 22.5 (10.3, 111.3) | 27.8 (17.8, 599) | 15.6 (10.3, 59.5) | 0.28 |
| Cardiac troponin I > 130 pg/mL | 10/41 (24.4) | 7/20 (35.0) | 3/21 (14.3) | 0.12 |
| NT-proBNP (pg/mL) | 756 (246, 2566) | 1319 (309, 2691.5) | 663 (225, 2524) | 0.42 |
| NT-proBNP >300 pg/mL | 31/41 (75.6) | 16/20 (80.0) | 15/21 (71.4) | 0.52 |
| D-dimer (μg/mL) | 5.1 (1.7, 21.0) | 16.5 (5.0, 21.0) | 2.3 (1.1, 7.6) | 0.01 |
| D-dimer >5 μg/mL | 20/44 (45.5) | 14/22 (63.6) | 6/22 (27.3) | 0.02 |
| Tumor necrosis factor –α (pg/mL) | 11.4 (8.1, 16.0) | 15.9 (10.3, 20.7) | 8.35 (7.5, 13.0) | 0.03 |
| Interleukin-6 (pg/mL) | 57.9 (36.0, 152.9) | 57.9 (47.5, 345.2) | 57.3 (19.2, 124.1) | 0.27 |
Data are expressed as the median (IQR) or n/N (%), p-values are from the Mann–Whitney U test, χ² test or Fisher’s exact test.
COVID-19, coronavirus disease 2019; ALT, alanine aminotransferase; AST, aspartate aminotransferase; NT-proBNP, amino-terminal pro-brain natriuretic peptide precursor.