Table 3.

ADME Properties of the selected NPASS compound.

NPASS compound ID	QPlogPo/w (−2.5 to 6.5)	QPlogS (−6.5 to 0.5)	QPlogHERG (above −5.0)	QPPCaco (<25%-poor, >500-great)	QPlogBB (−3 to 1.2)	QPPMDCK (<25%-poor, >500-great)	QPlogKp (−8.0 to −0.1)	QPlogKhsa (−1.5 to 1.5)
NPC214620	−1.19	−0.09	−2.24	180.67	−0.96	77.83	−4.61	−0.91
NPC52382	−0.78	−1.97	−3.55	384.25	−0.91	175.94	−3.97	−0.88
NPC270578	−0.78	−1.97	−3.55	384.25	−0.91	175.94	−3.97	−0.88
NPC473043	−1.02	−1.92	−3.24	113.29	−1.32	46.99	−5.01	−0.78
NPC175107	−2.75	−1.41	−3.34	65.68	−1.56	26.07	−5.47	−1.29
NPC22192	1.97	−5.89	−5.45	246.55	−1.52	108.91	−4.45	0.10
NPC169474	0.52	−3.52	−4.92	870.98	−0.68	426.10	−3.48	−0.56
NPC297657	0.38	−2.61	−3.92	131.17	−1.50	55.06	−4.79	−0.43
NPC19721	0.02	−1.53	−3.38	54.84	−1.76	21.45	−5.43	−0.61
NPC279121	0.55	−1.89	−2.97	100.45	−1.31	41.27	−5.11	−0.33
NPC10737	0.42	−3.37	−4.68	516.13	−0.95	242.04	−3.82	77.97
NPC137813	−1.52	−2.57	−5.05	713.22	−0.74	352.70	−3.72	−1.48
NPC191146	3.08	−4.94	−4.32	1406.61	−0.43	715.33	−2.98	0.36
NPC3825	0.98	−3.29	−4.12	316.75	−1.05	142.79	−4.23	−0.32
NPC161224	−8.84	2.00	−4.83	5.58	−1.58	4.22	−8.63	−3.37
NPC226294	−1.15	−1.88	−3.67	178.04	−1.31	76.60	−4.53	−0.95
NPC19709	−0.891	−1.973	−3.159	259.635	−0.931	115.172	−4.401	−0.766
NPC61506	1.18	−2.972	−4.431	85.894	−1.889	34.841	−5.047	−0.226
NPC107109	0.436	−0.906	−2.725	607.8894	−0.55	288.864	−3.683	−0.769
NPC130230	0.50	−1.06	−2.60	154.93	−1.13	65.92	−4.65	−0.58
NPC175552	0.08	−1.76	−3.51	203.24	−1.22	88.39	−4.42	−0.60