Table I.
Demographic and clinical characteristic of the patients at baseline
| Characteristic | Total | Control group |
Ruxolitinib group |
P value |
|---|---|---|---|---|
| (N = 21) | (N = 20) | |||
| Age (y) | 63 (58-68) | 64 (59-71) | 63 (51-65) | .123 |
| Sex | >.999 | |||
| Female | 17 (41.5) | 9 (42.9) | 8 (40.0) | |
| Male | 24 (58.5) | 12 (57.1) | 12 (60.0) | |
| Comorbidity | 27 (65.9) | 13 (61.9) | 14 (70.0) | .744 |
| Hypertension | 16 (39.0) | 9 (42.9) | 7 (35.0) | .751 |
| Diabetes | 8 (19.5) | 3 (14.3) | 5 (25.0) | .454 |
| Coronary artery heart disease | 3 (7.3) | 1 (4.8) | 2 (10.0) | .606 |
| Smoking history | 4 (9.8) | 2 (9.5) | 2 (10.0) | >.999 |
| Respiratory rate >24 breaths/min | 8 (19.5) | 4 (19.0) | 4 (20.0) | >.999 |
| Pulse ≥125 beats/min | 7 (17.1) | 3 (14.3) | 4 (20.0) | .697 |
| Fever (temperature ≥37.3°C) | 5 (12.2) | 2 (9.5) | 3 (15.0) | .663 |
| White-cell count (×109/L) | 8.4 (6.1-11.0) | 8.3 (6.7-11.0) | 8.4 (5.6-11.0) | .652 |
| <4 | 2 (4.9) | 0 (0.0) | 2 (10.0) | .512 |
| 4-10 | 26 (63.4) | 14 (66.7) | 12 (60.0) | |
| >10 | 13 (31.7) | 7 (33.3) | 6 (30.0) | |
| Lymphocyte count (×109/L) | 1.1 (0.92-1.6) | 1.2 (0.97-2.0) | 1.0 (0.76-1.2) | .084 |
| ≥1.0 | 25 (61.0) | 15 (71.4) | 10 (50.0) | .208 |
| <1.0 | 16 (39.0) | 6 (28.6) | 10 (50.0) | |
| Platelet count | 264 (173-314) | 214 (175-285) | 297 (165-355) | .114 |
| ≥100 | 36 (87.8) | 19 (90.5) | 17 (85.0) | .663 |
| <100 | 5 (12.2) | 2 (9.5) | 3 (15.0) | |
| Serum creatinine (μmol/L) | 67 (56-75) | 66 (60-74) | 69 (52-75) | .872 |
| ≤133 | 38 (92.7) | 20 (95.2) | 18 (90.0) | .606 |
| >133 | 3 (7.3) | 1 (4.8) | 2 (10.0) | |
| Aspartate aminotransferase (U/L) | 36 (23-68) | 35 (19-88) | 39 (26-52) | .742 |
| ≤40 | 24 (58.5) | 13 (61.9) | 11 (55.0) | .758 |
| >40 | 17 (41.5) | 8 (38.1) | 9 (45.0) | |
| Alanine aminotransferase (U/L) | 25 (17-46) | 23 (18-50) | 26 (17-47) | .841 |
| ≤50 | 30 (73.2) | 15 (71.4) | 15 (75.0) | >.999 |
| >50 | 11 (26.8) | 6 (28.6) | 5 (25.0) | |
| Lactate dehydrogenase (U/L) | 275 (225-413) | 300 (226-438) | 262 (213-384) | .489 |
| ≤245 | 16 (39.0) | 8 (38.1) | 8 (40.0) | >.999 |
| >245 | 25 (61.0) | 13 (61.9) | 12 (60.0) | |
| Albumin (g/L) | 32.0 (30.0-34.0) | 32.0 (30.0-34.0) | 32.0 (30.0-35.0) | .821 |
| ≤35 | 32 (78.0) | 17 (81.0) | 15 (75.0) | .719 |
| >35 | 9 (22.0) | 4 (19.0) | 5 (25.0) | |
| D-Dimer (μg/mL) | 2.4 (0.65-7.5) | 2.5 (0.68-15.0) | 2.1 (0.62-3.5) | .248 |
| ≤1.0 | 14 (34.1) | 6 (28.6) | 8 (40.0) | >.999 |
| >1.0 | 23 (56.1) | 13 (61.9) | 10 (50.0) | |
| Missing data | 4 (9.8) | 2 (9.5) | 2 (10.0) | |
| High-sensitive cardiac troponin I (ng/mL) | 3.5 (2.0-6.3) | 3.0 (1.6-6.8) | 4.1 (2.2-6.5) | .483 |
| ≤28.0 | 33 (80.5) | 18 (85.7) | 15 (75.0) | .653 |
| >28.0 | 5 (12.2) | 2 (9.5) | 3 (15.0) | |
| Missing data | 3 (7.3) | 1 (4.8) | 2 (10.0) |
Data are median (IQR) or n (%).