Table 2. Test-retest reliability and estimates of meaningful change.

Intraclass correlation coefficients (ICCs), standard error of the measure (SEM) and minimal detectable change (MDC₉₀) for the 6 AAV-PRO scales/domains.

AAV-PRO Scale (number of items)	ICC^a	95%CI	Baseline mean raw score (SD)	SEM^b Raw score	SEM^b 0–100 scale	MDC₉₀^c Raw score	MDC₉₀^c 0–100 scale
Organ Specific Symptoms (5)	0.89	0.84 to 0.93	6.91 (4.70)	1.56	7.80	3.64	18.20
Systemic Symptoms (4)	0.91	0.87 to 0.94	7.21 (4.40)	1.32	8.25	3.08	22.75
Treatment side effects (5)	0.95	0.93 to 0.97	7.17 (4.43)	0.99	4.95	2.31	11.55
Social and Emotional Impact (6)	0.96	0.94 to 0.97	9.88 (6.24)	1.25	5.21	2.91	12.13
Concerns about the Future (5)	0.95	0.92 to 0.97	8.83 (5.35)	1.20	6.00	2.79	13.95
Physical Function (4)	0.96	0.94 to 0.97	5.22 (4.17)	0.83	5.19	1.94	12.13

ICC based on USA sample only, while SEM uses baseline scores from all USA/UK respondents combined.

SEM = SD × √1 – ICC. Computed using raw scores with scale converted to 0–100 metric at the end.

Example - for Organ Symptom Severity scale: SEM = 4.70 × √1−0.89 = 1.56 then Convert to 0–100 scale: 1.56 × 100/20 = 7.80

MDC₉₀ = 1.65 × (√2) X SEM. Computed using raw scores with scale converted to 0–100 metric at the end.

Example - for Systemic Symptom Severity scale: MDC₉₀ = 1.65 × 1.41 × 1.32 = 3.08 then Convert to 0–100 scale: 3.64 × 100/16 = 22.75