Table 4. Longitudinal construct validity.

Mean changes (SD), (using 0–100 metric), and effect sizes for the AAV-PRO domains in relation to patients‟ responses to a transition item on 3-month follow-up survey.

Transition item: “How are you NOW (in terms of your vasculitis and any treatment side-effects) compared with 3 months ago (when you first answered the questionnaire)?”	AAV-PRO DOMAINS
Responses:	ORGAN SYMPTOM SEVERITY Mean (SD) [ES]	SYSTEMIC SYMPTOM SEVERITY Mean (SD) [ES]	TREATMENT SIDE-EFFECTS Mean (SD) [ES]	SOCIAL & EMOTIONAL IMPACT Mean (SD) [ES]	CONCERNS ABOUT THE FUTURE Mean (SD) [ES]	PHYSICAL FUNCTION Mean (SD) [ES]
Much better	n=38 3.68 (13.79) [0.22]	n=40 6.09 (13.68) [0.21]	n=39 4.62 (12.16) [0.28]	n=40 5.31 (12.27) [0.21]	n=40 6.13 (14.57) [0.23]	n=41 5.79 (15.08) [0.24]
Slightly better	n=69 0.72 (14.86) [0.01]	n=68 2.76 (11.85) [0.07]	N=69 2.03 (12.44) [0.10]	n=72 2.37 (13.36) [0.09]	n=71 3.87 (16.52) [0.17]	N=73 5.05 (10.66) [0.19]
No change/worse	n=186 0.54 (15.09) [0.01]	n=186 0.44 (15.37) [0.00]	n=185 1.24 (13.12) [0.09]	n=190 1.58 (11.18) [0.06]	n=187 1.66 (13.62) [0.05]	n=193 0.32 (9.43) [0.01]
Slightly worse	n=64^a −1.64 (16.67) [−0.07]	n=63 −5.46 (17.84) [−0.19]	n=62 −0.81 (15.92) [−0.01]	n=65^a 0.26 (16.02) [0.04]	n=63 −0.87 (17.36) [−0.02]	n=65 −3.08 (18.52) [−0.17]
Much worse	n=14 1.43 (11.17) [0.06]	n=15 −6.25 (18.15) [−0.23]	n=14 −10.71 (16.04) [−0.45]	n=15^a −7.78 (15.42) [−0.26]	n=15 −13.67 (16.85) [−0.43]	n=15 −9.58 (27.84) [−0.31]
P-value for linear trend	0.185	<0.001	0.001	0.003	<0.001	<0.001
Total	n=374 0.64 (15.06) [0.02]	n=377 0.22 (15.43) [−0.01]	n=373 0.95 (13.71) [0.07]	n=387 1.53 (12.90) [0.06]	n=381 1.44 (15.41) [0.05]	n=392 0.91 (13.69) [0.03]

The ‘n’ in each cell varies slightly across the rows reflecting an occasional missing patient’s response to an item within the health status scale (hence the particular overall scale would not have been computed for that individual).