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. 2020 May 19;11:737. doi: 10.3389/fphar.2020.00737

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Copyright © 2020 Li, Yu, Zhou, Chen, Li, Zheng, Zeng, Long and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CCT020312 induced G1 phase arrest in TNBC cells. (A, B) MDA-MB-453 cells (A) and CAL-148 cells (B) were treated with CCT020312 at different concentrations for 24 h. The flow cytometry was used to analyze the cell cycle data (n = 3). Data are presented as mean ± SD. (C, D) MDA-MB-453 cells (C) and CAL-148 cells (D) were treated with various of CCT020312 for 24 h, or treated with 8 and 10 μM CCT020312 for indicated time, then cells were collected to detect CDK4, CDK6, and cyclin D1 level using Western blotting.