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CCT020312 suppressed AKT/mTOR signaling. (A, B) GEPIA dataset (http://gepia.cancer-pku.cn/) was used to analyze the AKT/mTOR pathway in breast cancer in relation to ATF4 (A) and CHOP (B). CHOP also known as DDIT3. (C, D) MDA-MB-453 cells (C) and CAL-148 cells (D) were treated with 8 and 10 μM CCT020312 for indicated time, then cells were collected to detect AKT, p-AKT, mTOR, and p-mTOR level using Western blotting.
