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. 2020 May 19;11:737. doi: 10.3389/fphar.2020.00737

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Copyright © 2020 Li, Yu, Zhou, Chen, Li, Zheng, Zeng, Long and Zhou

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CCT020312 inhibited tumor growth in an MDA-MB-453 cell orthotopic xenograft mouse model. (A) Tumor volumes were measured every three days and differed at the end of the treatment period (n = 5). Data are presented as mean ± SD, *p < 0.01 vs. control. (B) Body weight changes in mice during the 21 days of CCT020312 treatment (n = 5). Data are presented as mean ± SD. (C) Representative tumor tissues were sectioned and subjected to immunohistochemistry staining (magnification, × 400). (D) Representative tumor tissues from each group were prepared and subjected to Western blotting assay.