Figure 1.

Integrin-mediated adhesion and integrin expression in LAD2 mast cells at the gene level under the influence of hypoxia. (a) LAD2 mast cell adhesion to selected extracellular matrix proteins assessed after 72 hours of incubation in 21% (Normoxia) or 5% (Hypoxia) oxygen. For FN mean ± SEM. COL I–IV, collagen type I–IV; FN, fibronectin; LN, laminin; VN, vitronectin; (b) Relative change in adhesion after incubation in different oxygen concentrations compared to atmospheric condition. Adhesion in 21% oxygen was arbitrarily accepted as 1. Mean ± SEM. * p < 0.05, paired t-test. (c) The mRNA expression of different genes encoding integrin subunits was measured after 72 hours incubation in 21% (Normoxia) or 1% (Hypoxia) oxygen. Mean ± SEM. * p < 0.05, paired t-test.