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Drug and Metabolite Concentrations in Plasma And PBMCs 2–24 h After an IV 10-mg/kg Dose in Monkey [1]
| Remdesivir (inactive) plasma | Alanine metabolite (inactive) plasma | Nucleoside (Nuc) (active) plasma | Nucleoside triphosphate (Nuc-TP) (active) plasma | Nucleoside triphosphate (Nuc-TP) (active) PBMC | |
|---|---|---|---|---|---|
| 0.5 h | ~ 1 μM | ~ 2 μM | ~ 1 μM | ND | ND |
| 2 h | < 0.1 μM | < 0.5 μM | ~ 1 μM | ND | 30–40 μM |
| 8 h | ND | < 0.2 μM | ~ 0.4 μM | ND | 20–30 μM |
| 24 h | ND | ND | < 0.2 μM | ND | 20–30 μM |
ND, not detected
