Table 4.
Multivariable analysis of demographic, ophthalmic, and tumor factors associated with quality of life
| Demographic (p value, R2) | Ophthalmic (p value, R2) | Tumor (p value, R2) | |
|---|---|---|---|
| Global health status | PS (<0.01, 0.14) | VA eye with melanoma (<0.01, 0.21) | |
| Functional scales | |||
| Physical functioning | PS (<0.01, 0.25) age (<0.01, 0.39) comorbidity (<0.01, 0.45) sex (0.03, 0.47) |
||
| Role functioning | PS (<0.01, 0.22) comorbidity (0.02, 0.32) sex (0.01, 0.37) |
VA eye with melanoma (<0.01, 0.28) | anterior border (0.03, 0.40) |
| Emotional functioning | comorbidity (0.03, 0.05) sex (<0.01, 0.12) |
||
| Cognitive functioning | PS (<0.01, 0.18) children (0.02, 0.23) |
||
| Social functioning | PS (<0.01, 0.08) | VA eye with melanoma (0.04, 0.12) best VA (0.01, 0.18) | |
| Symptom scales/items | |||
| Fatigue | PS (<0.01, 0.12) age (0.01, 0.18) |
||
| Nausea and vomiting | PS (0.02, 0.06) | ||
| Pain | comorbidity (<0.01, 0.19) | ||
| PS (<0.01, 0.27) | |||
| Dyspnea | age (<0.01, 0.07) | ||
| Insomnia | PS (0.04, 0.05) | posterior border (0.04, 0.09) | |
| Appetite loss | PS (0.02, 0.05) | ||
| Constipation | PS (<0.01, 0.26) age (0.01, 0.31) |
||
| Diarrhea | children (<0.01, 0.12) ethnicity (<0.01, 0.19) |
IOP eye without melanoma (0.01, 0.24) | |
| Financial difficulties | |||
| Ocular irritation | ethnicity (<0.01, 0.08) | retinal detachment (0.04, 0.21) | |
| marriage (<0.01, 0.17) | |||
| Vision impairment | VA eye with melanoma (<0.01, 0.28) | extraocular extension (0.03, 0.50) | |
| VA best eye (<0.01, 0.42) | |||
| IOP eye with melanoma (0.03, 0.46) | |||
| Headaches | |||
| Worry about recurrent disease | |||
| Problems driving | marriage (0.03, 0.42) ethnicity (0.04, 0.46) |
VA eye with melanoma (<0.01, 0.34) | anterior border (0.02, 0.38) |
| Problems with appearance | VA eye with melanoma (<0.01, 0.08) | ||
| Functional problems due to vision impairment | PS (<0.01, 0.40) marriage (0.03, 0.44) ethnicity (0.04, 0.46) |
VA eye with melanoma (<0.01, 0.30) | |
| Problems with reading | VA eye with melanoma (<0.01, 0.21) retinal detachment (<0.01, 0.28) | extraocular extension (0.02, 0.32) | |
| QOL, quality of life; PS, performance status; VA, visual acuity; IOP, intraocular pressure. | |||
| R2 = 0.01–0.19 | |||
| 0.20–0.39 | |||
| 0.40–0.49 | |||
| 0.50 | |||