TABLE 5.

Half-lives of seven drugs in male and female primary rat hepatocytes

Drug	Rat sex	t1/2	P valuea
		mean ± S.D., min
Azelastine	Male	61 ± 7	0.042
	Female	107 ± 34
Buspirone	Male	70 ± 11	0.023
	Female	132 ± 36
Fentanyl	Male	35 ± 2	0.002
	Female	52 ± 5
Glimepiride	Male	194 ± 74	0.027
	Female	329 ± 45
Tamsulosin	Male	31 ± 1	0.018
	Female	43 ± 6
Pravastatin	Male	263 ± 265	0.481
	Female	255 ± 77
Tazarotene	Male	17 ± 2	0.281
	Female	16 ± 2

^aComparison of drug half-life in males and females.