Fig. 2.
The overall workflow for developing and verifying the full-body parent-metabolite PBPK model of methamphetamine and amphetamine for the simulation of urine pH-dependent systemic disposition and urinary excretion. AAFE, absolute average fold error; B/P, blood-to-plasma ratio; CLiv, total body clearance measured after intravenous dosing; CLpo, total body clearance measured after oral dosing; CLr, renal clearance; M/P, metabolite-to-parent ratio; Papp, experimentally determined apparent cellular permeability; PET, positron emission tomography.