Fig. 3.

Simulation of methamphetamine (Meth) plasma concentration-time profiles after intravenous dosing. The simulated plasma concentrations (shown in red) were compared to the observed data (shown in blue) from six different test sets. The calculated AAFE value for each dataset is shown in each panel. The observed data for methamphetamine are from (A) (Cook et al., 1993), (B) (Mendelson et al., 1995), (C) (Harris et al., 2003), (D) (Harris et al., 2003), (E) (Mendelson et al., 2006), and (F) (Mendelson et al., 2006).