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Simulation of methamphetamine (Meth) and amphetamine (Amph) plasma concentration-time profiles after oral dosing. The simulated plasma concentrations (red lines) were compared to the observed data (blue circles) from three different test sets. The calculated AAFE value for each data set is shown in each panel. The observed data for methamphetamine (A) are from Perez-Reyes et al. (1991), and the observed data for amphetamine (B and C) are from CDER (2002).
