TABLE 3.
Ca2+ mobilization potencies for ligands at various primate OTRs
Data are presented as means ± log S.E.M.
| OTR (n = 3) | Ca2+ EC50 |
||
|---|---|---|---|
| Pro8-OT | Leu8-OT | AVP | |
| nM | |||
| Human | 0.072 ± 0.12 | 0.127 ± 0.10 | 0.864 ± 0.07a,b |
| Macaque | 1.341 ± 0.11 | 2.025 ± 0.11 | 7.981 ± 0.12a,b |
| Marmoset | 0.115 ± 0.15 | 0.176 ± 0.14 | 0.459 ± 0.14b |
| Titi monkey | 0.595 ± 0.09 | 1.010 ± 0.09 | 4.821 ± 0.09a,b |
a
Indicates a significant within-species difference compared with Leu8-OT using a Bonferroni-corrected cutoff of P < 0.0167.
b
Indicates a significant within-species difference compared with Pro8-OT using a Bonferroni-corrected cutoff of P < 0.0167.