Table 2.

Classification of pathogenic/likely pathogenic variants and VUS results by risk profile

		Pathogenic n=25 (%)	VUS n=40 (%)*
High risk	APC	1 (4)
	BRCA1	9 (36)	3 (7.5)
	BRCA2	10 (40)	6 (15)
	CDH1		2 (5)
	CDKN2A		1 (2.5)
	MLH1		1 (2.5)
	MSH2		1 (2.5)
	MSH6		3 (7.5)
	MUTYH	3 (12)	1 (2.5)
	PMS2		3 (7.5)
	PTEN		3 (7.5)
	STK11		1 (2.5)
	TP53	1 (4)
Moderate risk	ATM		8 (20)
	CHEK2		1 (2.5)
	NF1		1 (2.5)
	PALB2	1 (4)	2 (5)
Newer genes	RAD50		2 (5)
	RAD51		1 (2.5)

^*Thirty-four study participants had VUS results, however five participants had more than one VUS detected.