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ROC curve for angiopoietin-2 cut-off in direct ICU admission. Angiopoietin-2 level above 5000 pg/mL was identified using Youden index method as a potential criteria for COVID-19 transfer in ICU (AUC 77.12, 95% CI 62.4–91.9). AUC for area under the curve; CI for confidence interval; PPV for positive predictive value; NPV for negative predictive value. R for Kendall rank correlation coefficient; CRP for C-reactive protein
