Table 2.
Biological characteristics of COVID-19 patients at admission according to level of care (medical ward or ICU direct admission)
| Medicine patients (n = 20) | ICU patients (n = 20) | p value | |
|---|---|---|---|
| Biological parameters, median [IQR] | |||
| White blood cells—× 109 per L | 6.15 [4.30, 7.45] | 7.20 [4.75, 11.25] | 0.267 |
| Hemoglobin—g/L | 143 [127.8, 152.5] | 128 [120.5, 139] | 0.066 |
| Platelet count—× 109 per L | 205.5 [151.3, 238] | 165 [135, 217] | 0.361 |
| Polynuclear neutrophils—× 109 per L | 4.43 [3.10, 5.53] | 4.38 [3.58, 10.48] | 0.187 |
| Lymphocytes—× 109 per L | 0.95 [0.80, 1.35] | 0.68 [0.46, 1.10] | 0.038 |
| Monocytes—× 109 per L | 0.38 [0.29, 0.55] | 0.33 [0.19, 0.62] | 0.391 |
| CRP—mg/L | 76.8 [31.9, 101.2] | 146 [101.3, 204.8] | 0.002 |
| Plasma creatinine—µmol/L | 67 [61.3, 83.5] | 115 [76.5, 215.5] | 0.001 |
| PT ratio | 0.96 [0.94, 0.10] | 0.88 [0.81, 12] | 0.132 |
| Fibrinogen—g/L | 5.3 [4.6, 5.9] | 6.3 [5.4, 6.7] | 0.019 |
| D-dimers ≥ 1000 ng/mL—n (%) | 6 (30) | 12 (60) | 0.069 |
| D-dimers—ng/mL | 732 [512, 1063] | 1128 [885, 2151] | 0.008 |
| Fibrin monomers—µg/mL | < 7 [< 7, < 7] | < 7 [< 7, < 7] | 0.270 |
| Angiogenic parameters (pg/mL), median [IQR] | |||
| Angiopoietin-1 | 4139.4 [3042.2, 8755.5] | 5083.2 [2928.5, 7349.9] | 0.935 |
| Soluble endoglin | 1958.6 [1357.5, 2421.6] | 1934.9 [1568.8, 2255.1] | 0.925 |
| Leptin | 8531.4 [5059.2, 19,938.5] | 11,400.7 [5724.1, 25,004.7] | 0.552 |
| Soluble E-selectin | 37,930.5 [22227.1, 45,844.3] | 52,937.6 [35649, 71964] | 0.009 |
| VEGF-A | 23.6 [17.5, 34] | 24.5 [16.9, 34.5] | 0.839 |
| Angiopoietin-2 | 4385.7 [3185.9, 5667.1] | 6574.1 [5354.4, 11,375.9] | 0.003 |
| c-Kit | 12,809.7 [10535.3, 22,153.7] | 10,176.4 [6353.1, 22,024.2] | 0.218 |
| FGFb | 48.9 [34.2, 58.9] | 45 [34.8, 63.7] | 0.935 |
| PlGF | 42 [36.4, 47.6] | 43.7 [35.2, 53.4] | 0.482 |
| sVEGFR-2 | 15,153.2 [11619.2, 16,659.6] | 13,097.5 [10482.7, 17926] | 0.646 |
ICU intensive care unit
*Variable expressed as median [IQR]