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Mechanisms of TIGIT mediated suppression. TIGIT can block CD226-PVR mediated activation of T cells because it binds to CD226 with higher affinity than PVR (A). Ligation of TIGIT with PVR on naïve T cells blocks T cell priming, and triggers the production of the immunosuppressive molecule, FGL2 (B). Ligation of PVR with TIGIT promotes a regulatory dendritic cell that secretes IL-10 (C). Artwork by Ryan E. Lee.
