. Author manuscript; available in PMC: 2021 Aug 1.

Published in final edited form as: Hepatology. 2020 Apr 27;72(2):441–453. doi: 10.1002/hep.31046

Table 2.

Summary of Delta MELD score, bilirubin and aminotransferases in response to F-652.

	Day 0	Day 28	p-value	Day 42	p-value
Total Patients
Delta MELD (points)	-	−6.0 [−8.25, 0.75]	0.0054	−5.0 [−9.0, −2.0]	0.0003
Delta total bilirubin (mg/dL)	-	−3.7 ± 1.6	< 0.0001	−4.6 ± 1.6	0.0002
ALT (IU/L)	77.4 ± 10.4	42.46 ± 6.8	0.032	40.9 ± 7.2	0.026
AST (IU/L)	141.7 ± 18.5	77.2 ± 11	0.0062	79.8 ± 17.6	0.0149
Moderate AH (MELD:11-20)
Delta MELD (points)	-	−7.0 [−8.0, 0.0]	0.034	−3.0 [−10.0, 10.5]	0.023
Severe AH (MELD: 21-28)
Delta MELD (points)	-	−5.0 [−9.0, 3.0]	N.S.	−5.5 [−9.5, −2.25]	0.0014
EV concentration (particles/mL)	2.6X10¹¹ ± 1.9X10¹¹	4.7X10¹⁰ ± 2.1X10¹⁰	0.0125	8.2X10¹⁰ ± 3.3X10¹⁰	N.S.