Figure 1.

Schematic representation of relationships between mechanisms of action, evolution and dynamics. Green round box represents the mechanisms of action. If an action is functional it may have allosteric and/or orthosteric effects. If it is dysfunctional, it will not be selected against by the evolutionary pressure (Blue round box). The protein sequences and structures filtered by evolution will then perform their functions defined by intrinsic dynamics, during which various perturbations act through either physical or chemical changes (orange round box). These changes may alter the favorability of selected modes through which the protein perform actions. Gray square boxes represent four main stimuli that trigger allosteric responses.