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. Author manuscript; available in PMC: 2021 Jun 2.
Published in final edited form as: Angew Chem Int Ed Engl. 2020 Mar 24;59(23):9143–9148. doi: 10.1002/anie.202001824

Table 4.

One-step direct alkylation of pharmaceutically relevant compounds from carboxylic acidsa,b

graphic file with name nihms-1576748-t0009.jpg
a

Reaction conditions: carboxylic acid component (0.10 mmol), Bn-HE 2a (0.15 mmol), Az-1 (0.015 mmol), Cs2CO3 (0.015 mmol), PC-1 (1 μmol), CH3CN (0.1 M) for 36 h.

b

Isolated yield.