Table 5.

Normalization of disturbed sleep–wake rhythm during 1 year and outcome at 8 years

Measure at 8 years	Crude univariate model		Adjusted model 1		Adjusted model 2		Adjusted model 3
	B (SE)	p	B (SE)	p	B (SE)	p	B (SE)	p
BDI-21 total score at 8 years	− 0.29 (0.12)	0.02*	− 0.30 (0.13)	0.02*	− 0.30 (0.13)	0.03*	− 0.30 (0.14)	0.04*
HDRS total score at 8 years	− 0.23 (0.11)	0.04*	− 0.25 (0.12)	0.04*	− 0.27 (0.12)	0.03*	− 0.27 (0.13)	0.04*
BAI total score at 8 years	− 0.25 (0.12)	0.03*	− 0.25 (0.12)	0.04*	− 0.26 (0.13)	0.04*	− 0.27 (0.13)	0.04*
GAF at 8 years	0.07 (0.03)	0.03*	0.07 (0.04)	0.04*	0.07 (0.04)	0.05*	0.07 (0.04)	0.10
GAF at 8 years; best during past y	0.07 (0.03)	0.02*	0.07 (0.03)	0.02*	0.07 (0.03)	0.02*	0.06 (0.03)	0.05*
% Time spent ill during 8 years	− 0.08 (0.09)	0.42	− 0.06 (0.10)	0.54	NA	NA	− 0.03 (0.10)	0.74

As supplementary analyses, the depressed adolescents with sleep–wake rhythm at baseline who did not show this symptom anymore at 1-year follow-up (n = 18) were compared with the rest of the adolescents (n = 79; reference category)

Adjusted model 1 has been adjusted for gender and age at baseline

Adjusted model 2 has been adjusted for gender, age at baseline, and value of respective outcome variable at baseline

Adjusted model 3 has been adjusted for gender, age at baseline, and baseline values of BDI-21, BAI, and GAF, except for outcome HDRS at 8 years, where the model was adjusted for gender, age at baseline, and baseline values of HDRS, BAI, and GAF

SE standard error, NA not applicable

*p < 0.05