Table 1.

Parameters in ${\Sigma }_1$

Parameter	Value	Description	References
$D_1$	$3.5\times {10}^{-4}$	Diffusion coeff. for cell population $c_1$	Domschke et al. (2014)
$D_2$	$7\times {10}^{-4}$	Diffusion coeff. for cell population $c_2$	Domschke et al. (2014)
$D_m$	${10}^{-3}$	Diffusion coeff. for MDEs	Estimated
${\mu }_1$	0.25	Proliferation coeff. for cell population $c_1$	Domschke et al. (2014)
${\mu }_2$	0.25	Proliferation coeff. for cell population $c_2$	Domschke et al. (2014)
${\gamma }_1$	2	Non-fibrous ECM degradation coeff.	Shuttleworth and Trucu (2019)
${\gamma }_2$	1.5	Macroscopic fibre degradation coeff.	Peng et al. (2017)
${\alpha }_1$	1	MDE secretion rate of $c_1$	Estimated
${\alpha }_2$	1.5	MDE secretion rate of $c_2$	Estimated
R	0.15	Sensing radius	Shuttleworth and Trucu (2019)
r	0.0016	Width of micro-fibres	Shuttleworth and Trucu (2019)
$f_{\text{max}}$	0.6360	Max. micro-density of fibres	Shuttleworth and Trucu (2019)
p	0.15-0.2	Percentage of non-fibrous ECM	Estimated
h	0.03125	Macro-scale spatial discretisation size	Trucu et al. (2013)
$ϵ$	0.0625	Size of micro-domain $ϵY$	Trucu et al. (2013)
$\delta$	0.03125	Size of micro-domain $\delta Y$	Shuttleworth and Trucu (2019)