Table 3.

MVA^a for PDRS for dnMBC vs. early 24.

Covariate	HR (95% CI), p value
DENOVO (time-varying)
dnMBC	1 (Ref. category)
Early 24 (at 2 years)	2.53 (1.50–4.27), 0.00052
Early 24 (at 5 years)	2.42 (1.39–4.22), 0.0019
Early 24 (at 10 years)	3.88 (1.07–14.07), 0.039
Age at diagnosis (years)	1.01 (0.98–1.05), 0.458
BMI
BMI < 25	1 (Ref. category)
25 ≤BMI < 30	1.14 (0.84–1.53), p = 0.403
BMI ≥ 30	1.19 (0.86–1.65), p = 0.301
Grade
1	1 (Ref. category)
2	1.09 (0.24–4.89), p = 0.912
3	1.03 (0.23–4.51), p = 0.971
Max invasive size (mm)	1.00 (0.997–1.01), p = 0.384
N stage
N0	1 (Ref. category)
N1	1.42 (1.05–1.93), p = 0.024
HER2 status
Negative	1 (Ref. category)
Positive	0.66 (0.51–0.86), p = 0.002
Ethnicity
White/Caucasian	1 (Ref. category)
Black	0.61 (0.34–1.12), p = 0.114
Asian	1.63 (0.74–3.61), p = 0.225
Other	0.43 (0.10–1.77), p = 0.240
ER status (time-varying)
Negative	1 (Ref. category)
Positive (at 2 years)	0.50 (0.38–0.67), p < 0.0001
Positive (at 5 years)	0.79 (0.48–1.29), p = 0.350
Positive (at 10 years)	1.30 (0.52–3.25), p = 0.590

^aStpm2 model (Flexible parametric survival model). Time varying for dnMBC vs. early24 and ER status. However, no stratification of ethnicity incorporated into this model as non-time-varying.