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. 2020 May 26;10:8686. doi: 10.1038/s41598-020-65628-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Exosome miRNA Associated Cancer and Mechanosensitive Pathways. Comprehensive miRNA microarray analysis between SEC-exosome vs. CI-exosome showed that various miRNAs were differentially up- and downregulated between exosome populations. (A) Analysis was used to determine Log2 fold changes after FDR correction of representative, specific miRNAs that are associated to focal adhesions, actin cytoskeleton, and epithelial ovarian cancer. The compiled list of associated miRNAs was analyzed using DIANA TOOLS. Several miRNAs that were highly regulated overlapped in presented pathways. (B) A representative list of differentially regulated miRNAs between exosome populations were plotted in the volcano plot (gray) and examples of up- or downregulated miRNAs are highlighted for specific pathways, including focal adhesions (red), actin cytoskeleton (blue), and miRNAs in EOC (yellow).