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. 2020 Apr 15;122(11):1580–1589. doi: 10.1038/s41416-020-0814-x

Fig. 3. IDH1 mutants result in alterations throughout the epigenome.

Fig. 3

Owing to structural similarity, IDH1-mutant-derived D-2-HG serves as a competitive inhibitor for KDM4 or TET and therefore blocks the demethylation process in histone and nucleotide, respectively.