Table 2.

Transgenic mouse models for IDH-mutated glioma.

Mouse strain	DNA/virus construct	D-2-HG	Incidence	Median survival	References
Ntva, Ink4a-Arf−/−	RCAS-PDGF RCAS-IDH-H1-shp53	~100-fold	NA	WT: 36 days R132H: 35 days	112
Ntva, Cdkn2af/f, Ptenf/f, ATRXf/f	RCAS-Cre RCAS-PDGFA RCAS-IDH1-R132H	~100-fold	WT: 20% R132H: 88%	WT: 150 days R132H: 43.5 days	113
Ntva, Cdkn2af/f	RCAS/luc–PDGFB RCAS/YFP–IDH1R132H; RCAS/IDH1R132H–PDGFB	3583 nmol/mg protein	WT: 0% R132H: 93%	WT: NA R132H: 43 days	114,115
C57BL/6	pT2C-LucPGK-SB100X, pT2-shp53-GFP4, pT2CAG-NRASV12, pT2-shATRX53-GFP4, pKT-IDH1(R132H)-IRES-Katushka	8.16 μg/mg of protein	NA	WT: 70 days R132H: 163 days	83
Idh1LoxPR132H/+	Retrovirus PDGFB-IRES-CRE	Elevated	>90%	WT: 29 days R132H: 34 days	116

NA not applicable, WT wild type.