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. 2020 May 26;10:8685. doi: 10.1038/s41598-020-65518-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Protein-protein interaction (PPI) network of differentially expressed genes (DEGs) induced by GaAs in 16HBE cells. The PPI network was drawn using the NetworkAnalyst platform based on the STRING interactome. (a) The red circles represent upregulated genes, the green circles represent downregulated genes, and the grey circles indicate no DEGs. The top degree (>20) involved in the interaction network was screened; (b) The heatmap shows the expression level of the 17 key genes in the RNA-seq data.