Table 2.
The top genes ranked by degree over 20 in PPI analysis.
| Gene symbol | Description | KEGG Pathways | gene_chr | Degree | Betweenness | log2FoldChange (GaAs vs.NC) |
|---|---|---|---|---|---|---|
| AKT1 | v-akt murine thymoma viral oncogene homolog 1, protein_coding | Small cell lung cancer | 14 | 57 | 972.3 | −1.961368001 |
| TP53 | tumor protein p53, protein_coding | Small cell lung cancer, Cell cycle | 17 | 41 | 470.66 | −2.592326592 |
| JUN | jun proto-oncogene, protein_coding | Pathways in cancer, MAPK signaling pathway | 1 | 39 | 282.42 | 4.837850274 |
| ESR1 | estrogen receptor 1, protein_coding | Pathways in cancer | 6 | 37 | 337.46 | 1.787520803 |
| HSP90AA1 | heat shock protein 90 kDa alpha (cytosolic), class A member 1, protein_coding | Pathways in cancer | 14 | 34 | 417.35 | 3.926057435 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1), protein_coding | Pathways in cancer, Transcriptional misregulation in cancer | 6 | 34 | 301.04 | 3.632760311 |
| CDK1 | cyclin-dependent kinase 1, protein_coding | Cell cycle | 10 | 33 | 346.53 | −1.423420996 |
| RAC1 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), protein_coding | Pathways in cancer, MAPK signaling pathway | 7 | 33 | 297.85 | 1.045045893 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, protein_coding | Small cell lung cancer | 4 | 32 | 372.86 | −1.465472937 |
| SMAD3 | SMAD family member 3, protein_coding | Cell cycle | 15 | 32 | 242.91 | −1.428252719 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88 kDa, protein_coding | Pathways in cancer | 3 | 32 | 264.91 | 1.011091149 |
| MAPK8 | mitogen-activated protein kinase 8, protein_coding | Pathways in cancer, MAPK signaling pathway | 10 | 32 | 260.71 | 1.011586254 |
| MYC | v-myc myelocytomatosis viral oncogene homolog (avian), protein_coding | Pathways in cancer, MAPK signaling pathway, Transcriptional misregulation in cancer, TGF-beta signaling pathway | 8 | 31 | 190.63 | 1.439621447 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog, protein_coding | Pathways in cancer, MAPK signaling pathway | 14 | 28 | 98.25 | 7.328134023 |
| E2F1 | E2F transcription factor 1, protein_coding | Small cell lung cancer, Cell cycle | 20 | 21 | 72.8 | −2.011988593 |
| PLK1 | polo-like kinase 1, protein_coding | Cell cycle | 16 | 20 | 322.92 | −2.341394476 |
| FOXO1 | forkhead box O1, protein_coding | Pathways in cancer, Transcriptional misregulation in cancer | 13 | 23 | 93.93 | 1.906896342 |