Table 3.
Consistency between authors’ conclusions on progression-free survival surrogacy and quantitative arguments in favour of surrogacy according to the type of study.
| Authors’ conclusions on surrogacy | R² ≥ 0.6 at trial level | Other quantitative arguments in favour of surrogacy | No quantitative arguments |
|---|---|---|---|
| Individual patient data meta-analysis | |||
| Validation of surrogacy | 8 (73%) | 1 (9%) | 2 (18%) |
| Partial validation of surrogacy | 0 (0%) | 0 (0%) | 0 (0%) |
| No validation of surrogacy | 1 (14%) | 1 (14%) | 5 (71%) |
| Aggregated data meta-analysis | |||
| Validation of surrogacy | 16 (48%) | 7 (21%) | 10 (30%) |
| Partial validation of surrogacy | 3 (25%) | 0 (0%) | 9 (75%) |
| No validation of surrogacy | 2 (10%) | 0 (0%) | 18 (90%) |
| Single-trial analysis | |||
| Validation of surrogacy | NA | 0 (0%) | 3 (100%) |
| Partial validation of surrogacy | NA | 0 (0%) | 2 (100%) |
| No validation of surrogacy | NA | 1 (33%) | 2 (66%) |