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. 2020 May 26;10:8689. doi: 10.1038/s41598-020-65481-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Assessment of liver fibrosis in htgUGT1A-WT and SNP mice after high-fat Paigen diet (HFPD) treatment. (A) Representative hepatic sections of histological Sirius red staining and (B) computational quantification of Sirius red stained areas. Hepatic collagen deposition was significantly lower in htgUGT1A-SNP mice. (C–G) Gene expression levels of the profibrotic biomarkers collagen type 1 alpha 1 (Col1a1), transforming growth factor beta (TGF-β), connective tissue growth factor (CTGF), platelet-derived growth factor subunit B (PDGFB) and tissue inhibitor metalloprotease 1 (TIMP 1) as indicators for severity of liver fibrosis. Transcriptional activation of all depicted fibrosis marker genes was significantly lower in htgUGT1A-SNP mice. In case of TGF-β and CTGF, minor transcriptional inductions were detected in HFPD-treated htgUGT1A-SNP mice. Graphs are expressed as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001.