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. 2020 May 26;10:8689. doi: 10.1038/s41598-020-65481-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hepatic UGT1A regulation in htgUGT1A-WT and SNP mice after high-fat Paigen diet (HFPD) treatment. (A) Hepatic mRNA expression levels of UGT1A isoforms relative to mouse β-actin. In htgUGT1A-WT mice, HFPD treatment led to a significant transcriptional upregulation of all depicted UGT1A isoforms, whereas in the presence of SNPs UGT1A induction was reduced (UGT1A1 and UGT1A9) or absent and remained below those observed in WT carriers. (B) Western blot analysis of hepatic UGT1A3 protein quantity. Higher protein amount was detected in htgUGT1A-WT mice. Graphs are expressed as means ± standard deviation. n.s. not significant; *p < 0.05; **p < 0.01; ***p < 0.001.