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. 2020 May 26;10:8689. doi: 10.1038/s41598-020-65481-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Hepatic mRNA expression and nuclear protein quantity of nuclear receptors in htgUGT1A-WT and SNP mice after high-fat Paigen diet (HFPD) treatment. (A) Enhanced inhibition of farnesoid X receptor (FXR) mRNA expression level was detected in htgUGT1A-WT mice (58%) compared to htgUGT1A-SNP mice (36%). (B) Western blot analysis of nuclear peroxisome proliferator-activated receptor alpha (PPARα) protein levels. Significantly reduced PPARα protein amount was measured in HFPD-treated htgUGT1A-WT, in contrast to unchanged levels in the presence of SNPs. Graphs are expressed as means ± standard deviation. *p < 0.05; **p < 0.01; ***p < 0.001.