Fig. 1. Pre-test and post-test probability (ppp) plots displaying the risk of CIN3+ among hrHPV+ women triaged according to current (left) or new algorithms in Norway.

Risks >24% should trigger referral to colposcopy/biopsy (red zone), risks <1% suggest release to routine screening (green zone) and in-between risks suggest further surveillance with repeat testing (yellow zone). Current algorithm: Reflex cytology at cut-off ASC-US and hrHPV testing 12 months later if reflex cytology shows NILM. Women with ASC-US+ at reflex triage or persistent hrHPV+ at delayed triage are referred to colposcopy. Women who cleared hrHPV are released to routine screening. New algorithm: HPV16/18 genotyping followed by cytology. Reference to colposcopy if HPV1618+ & ASC-US+, or other hrHPV+ & ASCH+. Women are referred to delayed triage with hrHPV testing if HPV1618+ & NILM, or other hrHPV+ & ≤LSIL. Those with persistent hrHPV are referred to colposcopy and those who cleared hrHPV are released to routine screening. This figure has been produced using data from refs. ⁴ and ⁸.