Anti-inflammatory effect |
α-Tocopherylquinone |
RAW 264.7 cells |
|
IC50 = 34.92 μM, NO production↓ |
Hu et al., 2018
|
Luteolin-8-C-β-digitoxopyranoside |
RAW 264.7 cells |
|
IC50 = 16.12 μM, NO production↓ |
Hu et al., 2018
|
Luteolin-8-C-β-boivinopyranoside |
RAW 264.7 cells |
|
IC50 = 26.67 μM, NO production ↓ |
Hu et al., 2018
|
Isoorientin |
Swiss mice |
Indomethacin (5 mg/kg), dexamethasone (0.5 mg/kg) |
25 mg/kg ip., leukocytes, neutrophils, mononuclears↓, MPO activity↓ |
Zucolotto et al., 2009
|
Vicenin-2 |
Swiss mice |
Indomethacin (5 mg/kg), dexamethasone (0.5 mg/kg) |
25 mg/kg ip., leukocytes, neutrophils, mononuclears↓, MPO activity↓ |
Zucolotto et al., 2009
|
Spinosin |
Swiss mice |
Indomethacin (5 mg/kg), dexamethasone (0.5 mg/kg) |
25 mg/kg ip., leukocytes, neutrophils, mononuclears↓, MPO activity↓ |
Zucolotto et al., 2009
|
Orientin |
DMH induced colorectal cancer in rats |
|
10 mg/kg ip., TNF-α, IL-6, iNOS and COX-2 expression ↓ |
Thangaraj and Vaiyapuri, 2017
|
Neuroprotective effects |
1α,3β-dihydroxy-16-keto-24(31)-en-cycloartane |
PC12 cells |
|
0.05-0.42 μM against the glutamate-induced neurotoxicity |
Xu et al., 2016
|
31-Methoxyl-passifloic acid |
PC12 cells |
|
0.06-0.23 μM against the glutamate-induced neurotoxicity |
Xu et al., 2016
|
Cyclopassifloside II |
PC12 cells |
|
0.08-0.35 μM against the glutamate-induced neurotoxicity |
Xu et al., 2016
|
Cyclopassifloside VIII |
PC12 cells |
|
0.06-0.46 μM against the glutamate-induced neurotoxicity |
Xu et al., 2016
|
Cyclopassifloside XIV |
PC12 cells |
|
0.08-0.32 μM against the glutamate-induced neurotoxicity |
Xu et al., 2016
|
Luteolin |
PC12 cells |
|
50.0 μM, NGF-induced neurite outgrowth ↑ |
Xu et al., 2013
|
Piceatannol |
mouse embryonic stem cells |
|
2.5 µM, astrocyte differentiation↑ |
Arai et al., 2016
|
Anxiolytic-like effect |
Isoorientin |
Swiss albino mice |
Diazepam (2 mg/kg Ig.) |
40 and 80 mg/kg, time spent in open arms of the elevated plus-maze ↑ |
Deng et al., 2010
|
Luteolin-7-O-[2-rhamnosylglucoside] |
Swiss mice |
Diazepam (1 mg/kg Ig.) |
30 mg/kg, time spent in the open arms of the elevated plus maze test ↑ |
Coleta et al., 2006
|
Antidepressant-like effect |
Cyclopassiflosides IX |
ICR mice |
Clomipramine (50 mg/kg) |
50 mg/kg Ig., immobility time in forced swim and tail suspension test reduced by 22.72% and 39.26% |
Wang et al., 2013
|
Cyclopassiflosides XI |
ICR mice |
Clomipramine (50 mg/kg) |
50 mg/kg Ig., immobility time in forced swim and tail suspension test reduced by 19.16% and 43.12% |
Wang et al., 2013
|
Sedative-like activity |
Isoorientin |
Swiss albino mice |
Diazepam (2 mg/kg Ig.) |
40 mg/kg and 80 mg/kg, number of spontaneous activities↓ |
Deng et al., 2010
|
Vasorelaxation effect |
Piceatannol |
Isolated rat thoracic aorta |
|
30 μM, eNOS expression↑ |
Sano et al., 2011; Kinoshita et al., 2013
|
Piceatannol |
Human EA. hy926 endothelial cells |
|
20 μM, 48 h, eNOS expression↑ |
Kinoshita et al., 2013
|
Scirpusin B |
Isolated rat thoracic aorta |
|
30 μM, endothelium-derived NO↑ |
Sano et al., 2011
|
Melanin inhibition and collagen synthesis promotion |
Piceatannol |
Dermal Cells (SF-TY cells) |
|
4.5 μM, melanin synthesis↓; 5 μM increased collagen synthesis↑ |
Matsui et al., 2010
|
Isoorientin |
B16 melanoma cells |
|
100 μM, melanin content (47.2% reduction) ↓ |
Zhang et al., 2013
|
Chrysin 6-C-β-rutinoside |
B16 melanoma cells |
|
100 μM, melanin content (47.2% reduction) ↓, MITF, tyrosinase, TRP-1, and TRP-2 proteins levels ↓ |
Zhang et al., 2013
|
(6S,9R)-roseoside |
B16 melanoma cells |
|
100 μM, melanin content (37.3% reduction) ↓ |
Zhang et al., 2013
|
Antidiabetic activity |
Piceatannol |
db/db mice |
|
50 mg/kg, blood glucose levels↓ |
Uchida-Maruki et al., 2015
|
Piceatannol |
Humans |
|
20 mg/day for 56 days, the insulin sensitivity, BP and HR improvement |
Kitada et al., 2017
|
Antioxidant activity |
Scirpusin B |
DPPH |
Trolox |
5-40 μM, DPPH radical scavenging activities |
Sano et al., 2011
|
Piceatannol |
DPPH |
Trolox |
5-40 μM, DPPH radical scavenging activities |
Sano et al., 2011
|
Piceatannol |
BALB/cByJ Jcl mice |
|
10 mg/kg Ig., 14 days, number of astrocytes↑ |
Arai et al., 2016
|